API® GENERAL CURE fish remedy treats a wide variety of parasitic diseases including velvet, fish lice, hole-in-the-head disease (Hexamita spp. & Spironucleus), gill & skin flukes (Dactylogyrus & Gyrodactylus ). For use in both freshwater and saltwater aquariums. This fish remedy will not color the aquarium water. Size: 10 packets per box. For each 10 gallons of water, empty one packet directly into aquarium. Repeat dose after 48 hours. Wait another 48 hours then change 25% of the aquarium water and add fresh activated carbon or replace filter cartridge.